| A | B | C | D | E | F | G | H | I | J | K | L | M |
| N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
Name   |
City |
Profession |
Quest |
Members Only |
| Zeke | Al Kharid | Merchant | None | No |
| Zembo | Karamja | Bartender | Pirate's Treasure Alfred Grimhand Memorial Bar Crawl A Void Dance | No |
| Zemouregal | None | Mahjarrat | Defender of Varrock The Curse of Arrav Ritual of the Mahjarrat The World Wakes Dishonour among Thieves | Yes |
| Zenesha | East Ardougne | Armor Merchant | None | Yes |
| Zenkog | Dorgesh-Kaan | Merchant | None | Yes |
| Zhuka (bamboo merchant) | Waiko | Merchant | Curse of the Black Stone | Yes |
| Zimberfizz | Soul Wars Island | Minion | Nomad's Requiem | Yes |
| Zoe (zygomite trader) | East Ardougne | Zygomite buyer | None | Yes |
| Zombie farmer | Shilo Village | Farmer | None | Yes |
| Zombie pirate head | Mos Le'Harmless | Zombie Pirate | A Clockwork Syringe Pieces of Hate | Yes |
| Zombie Protester | Braindeath Island | Protester | Rum Deal | Yes |
| Zommy 'Brains' Walker | City of Um | Musician | That Old Black Magic | No |
| Zoo keeper | Ardougne | Zookeeper | None | Yes |
| Zooknock | Ape Atoll | Gnome mage | Monkey Madness Recipe for Disaster: Freeing King Awowogei | Yes |
